Publication details


S. Drulhe, G. Ferrari-Trecate, H. de Jong, and A. Viari. Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks. In J. Hespanha and A. Tiwari, editors, Proc. 9th International Workshop on Hybrid Systems: Computation and Control , volume 3927 of Lecture Notes in Computer Science , pages 184--199. Springer-Verlag, 2006.


Recent advances of experimental techniques in biology have led to the production ofenormous amounts of data on the dynamics of genetic regulatory networks. In this paper,we present an approach for the identification of PieceWise-Affine (PWA) models ofgenetic regulatory networks from experimental data, focusing on the reconstruction ofswitching thresholds associated with regulatory interactions. In particular, our methodtakes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.