R. Porreca, G. Ferrari-Trecate, D. Chieppi, L. Magni, and O. Bernard. Switch detection in genetic regulatory networks. In A. Bemporad, A. Bicchi, and G. Buttazzo, editors, Proc. 10th International Workshop on Hybrid Systems: Computation and Control , volume 4416 of Lecture Notes in Computer Science , pages 754--757. Springer-Verlag, 2007.
This paper considers piecewise affine models of genetic regulatory networks and focuses on the problem of detecting switches amongdifferent modes of operation in gene expression data. This task constitutes the first step of a procedure for the complete identification of thenetwork. We propose two methods and illustrate the application to thereconstruction of switching times in data produced by a piecewise affinemodel of the network regulating the carbon starvation response in Es-cherichia coli.